JOSAMYCIN

CasNo 16846-24-5
Purity 99%

Inquery

Quality products?make an important contribution to long-term revenue and profitability. 99% Purity Commercial production JOSAMYCIN 16846-24-5 with Cheapest Price

1.What is the JOSAMYCIN ?

As a 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Josamycin can be particularly used in the treatment of Mycoplasma infection.Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

: 16846-24-5
josamycin

: 77405-60-8
(11E,13E)-(4R,5S,6S,7R,9R,16R)-7-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4,6-dihydroxy-5-methoxy-9,16-dimethyl-oxacyclohexadeca-11,13-diene-2,10-dione

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 92 percent / LiAl(O-t-Bu)3H / tetrahydrofuran / 0 °C 2: 1.) m-chloroperbenzoic acid, 2.) (CF₃CO)2O, pyridine, 3.) K₂CO₃, CH₃OH / 1) CH₂Cl₂, 0 deg C; 2) CH₂Cl₂, 0 - 25 deg C; 3) -10 deg C, 10 min 3: 80 percent / DDQ / benzene / 25 °C 4: 89 percent Turnov_. / p-TsOH / tetrahydrofuran / 60 °C 5: 70 percent / K₂CO₃, CH₃OH / 5 h / 0 °C 6: 90 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 25 °C With pyridine; methanol; dmap; potassium carbonate; toluene-4-sulfonic acid; lithium tri-t-butoxyaluminum hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; benzene;

Yield

Multi-step reaction with 6 steps

1: 92 percent / LiAl(O-t-Bu)3H / tetrahydrofuran / 0 °C

2: 1.) m-chloroperbenzoic acid, 2.) (CF₃CO)2O, pyridine, 3.) K₂CO₃, CH₃OH / 1) CH₂Cl₂, 0 deg C; 2) CH₂Cl₂, 0 - 25 deg C; 3) -10 deg C, 10 min

3: 80 percent / DDQ / benzene / 25 °C

4: 89 percent Turnov_. / p-TsOH / tetrahydrofuran / 60 °C

5: 70 percent / K₂CO₃, CH₃OH / 5 h / 0 °C

6: 90 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 25 °C

With pyridine; methanol; dmap; potassium carbonate; toluene-4-sulfonic acid; lithium tri-t-butoxyaluminum hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; benzene;

: 16846-24-5
josamycin

: 77234-54-9,77286-12-5
(7E,9E)-(1R,5R,12R,14R,15S,19S)-14-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-19-methoxy-5,12,17,17-tetramethyl-4,16,18-trioxa-bicyclo[13.3.1]nonadeca-7,9-diene-3,11-dione

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 92 percent / LiAl(O-t-Bu)3H / tetrahydrofuran / 0 °C 2: 1.) m-chloroperbenzoic acid, 2.) (CF₃CO)2O, pyridine, 3.) K₂CO₃, CH₃OH / 1) CH₂Cl₂, 0 deg C; 2) CH₂Cl₂, 0 - 25 deg C; 3) -10 deg C, 10 min 3: 80 percent / DDQ / benzene / 25 °C 4: 89 percent Turnov_. / p-TsOH / tetrahydrofuran / 60 °C 5: 70 percent / K₂CO₃, CH₃OH / 5 h / 0 °C 6: 90 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 25 °C 7: 95 percent / camphorsulfonic acid / acetone / 25 °C With pyridine; methanol; dmap; camphor-10-sulfonic acid; potassium carbonate; toluene-4-sulfonic acid; lithium tri-t-butoxyaluminum hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; acetone; benzene;

Yield

Multi-step reaction with 7 steps

1: 92 percent / LiAl(O-t-Bu)3H / tetrahydrofuran / 0 °C

2: 1.) m-chloroperbenzoic acid, 2.) (CF₃CO)2O, pyridine, 3.) K₂CO₃, CH₃OH / 1) CH₂Cl₂, 0 deg C; 2) CH₂Cl₂, 0 - 25 deg C; 3) -10 deg C, 10 min

3: 80 percent / DDQ / benzene / 25 °C

4: 89 percent Turnov_. / p-TsOH / tetrahydrofuran / 60 °C

5: 70 percent / K₂CO₃, CH₃OH / 5 h / 0 °C

6: 90 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 25 °C

7: 95 percent / camphorsulfonic acid / acetone / 25 °C

With pyridine; methanol; dmap; camphor-10-sulfonic acid; potassium carbonate; toluene-4-sulfonic acid; lithium tri-t-butoxyaluminum hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; acetone; benzene;

2.What is the CAS number for JOSAMYCIN ?

The CAS number of JOSAMYCIN is 16846-24-5.

More information of JOSAMYCIN 16846-24-5 are:

CAS?Number	16846-24-5
Density	1.2g/cm³
Melting Point	131.5℃
Boiling Point	877.8°Cat760mmHg
Flash Point	484.7°C
Vapor Pressure	0mmHg at 25°C
Refractive Index	1.6220 (estimate)
PSA	206.05000
LogP	3.01340
Pka	7.1 (40% aq methanol)

3.What are another words for JOSAMYCIN ?

Synonyms?for?JOSAMYCIN 16846-24-5:LeucomycinA3 (8CI);Oxacyclohexadecane, leucomycin V deriv.;Antibiotic YL 704A3;EN 141;Iosalide;Jomybel;Josacine;Josamina;Josamycin;Kitasamycin A3;Turimycin A5;Vilprafen;Wilprafen;? Josamycin;

4.What is the molecular formula of JOSAMYCIN?

The chemical formula of ?JOSAMYCIN is?C42H69 N O15 which containing 42 Carbon atoms,69 Hydrogen atoms,1 Nitrogen atoms and 15 Oxygen atoms,and the molecular weight of??JOSAMYCIN?is 828.02.

5.What is JOSAMYCIN (16846-24-5) used for?

Josamycin, a 16-membered ring macrolide antibiotic, is produced by certain strains of Streptomyces narbonensis var. josamyceticus. It is a white to yellowish-white powder with slight hygroscopic properties and is very soluble in methanol or ethanol, while being very slightly soluble in water. Josamycin exhibits antimicrobial activity against a wide range of pathogens, making it a valuable pharmaceutical compound.

InChI:InChI=1/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26?,27?,29+,30+,31-,34?,35?,36?,37?,38+,39+,40?,41?,42?/m1/s1

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Q: What is the JOSAMYCIN?

JOSAMYCIN is , while it's Molecular Formula is C42H69 N O15. As a 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Josamycin can be particularly used in the treatment of Mycoplasma infection.Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.